Journal of Siberian Federal University. Chemistry / Complex of Ceftriaxone with Mg(II): Synthesis, Structure, Spectral and Antibacterial Properties

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Issue
Journal of Siberian Federal University. Chemistry. 2023 16 (1)
Authors
Novikova, Galina V.; Tsyplenkova, Darya I.; Kuzubov, Alexander A.; Kolenchukova, Oksana A.; Samoilo, Alexander S.; Vorobyev, Sergey A.
Contact information
Novikova, Galina V.: Siberian Federal University, Krasnoyarsk, Russian Federation; ; Tsyplenkova, Darya I.: Siberian Federal University, Krasnoyarsk, Russian Federation; Kuzubov, Alexander A.: Siberian Federal University, Krasnoyarsk, Russian Federation; L.V. Kirensky Institute of Physics SB RAS Federal Research Center “Krasnoyarsk Science Center SB RAS” Krasnoyarsk, Russian Federation; Kolenchukova, Oksana A.: Siberian Federal University, Krasnoyarsk, Russian Federation; Scientific Research Institute of Medical Problems of the North Federal Research Center “Krasnoyarsk Scientific Center of the SB RAS” Krasnoyarsk, Russian Federation; Samoilo, Alexander S.: Siberian Federal University, Krasnoyarsk, Russian Federation; Vorobyev, Sergey A.: Institute of Chemistry and Chemical Technology SB RAS Federal Research Center “Krasnoyarsk Scientific Center of the SB RAS” Krasnoyarsk, Russian Federation
Keywords
cephalosporin antibiotic; ceftriaxone; magnesium; density functional theory; molecular spectroscopy; antibacterial screening
Abstract

Magnesium complex of ceftriaxone was obtained and characterized by atomic-emission and elemental analysis, TGA, FTIR and Raman spectroscopy, X‑ray diffraction and density functional theory calculations. Ceftriaxone was coordinated to the magnesium ion by the oxygen of the triazine cycle in the 6th position, the nitrogen of the amine group of the thiazole ring, and oxygen atoms of the lactam carbonyl and carboxylate groups. The disodium salt of ceftriaxone and magnesium complex were screened for antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa

Pages
5–15
EDN
YPNCXI
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/149960