Siberian Federal University

The Yuryev reaction was modified by replacing ammonia with aniline derivatives containing electron acceptors in the aromatic core: 2,4-dinitroaniline, p-nitrozoaniline, 4-aminoazobenzene. Under mild conditions of the reaction of furfural with p-aminoazobenzene and p- nitrozoaniline, a more stable intermediate compound, the Stenhouse salt, is formed, therefore, more stringent conditions were used to obtain the target nitrogen-functional N‑aryl‑2-formylpyrroles. As a result of mastering two techniques, 1-(2,4-dinitrophenyl)-2-formylpyrrol, 1-(4-nitrosophenyl)-2-formylpyrrol, 1-{4-[(E)-phenylazo]-phenyl}-2-formylpyrrol, potentially showing useful biological activity, were synthesized