Journal of Siberian Federal University. Chemistry / Preparation and Characterization of Rifampicin-Loaded poly(3-hydroxybutyrate-co‑3-hydroxyvalerate) Microparticles

Full text (.pdf)
Issue
Journal of Siberian Federal University. Chemistry. 2023 16 (2)
Authors
Dorokhin, Aleksei S.; Lipaikin, Sergei Y.; Ryltseva, Galina A.; Shishatskaya, Ekaterina I.; Kachin, Sergei V.
Contact information
Dorokhin, Aleksei S.: Siberian Federal University Krasnoyarsk, Russian Federation; ; Lipaikin, Sergei Y.: Siberian Federal University Krasnoyarsk, Russian Federation; Ryltseva, Galina A.: Siberian Federal University Krasnoyarsk, Russian Federation; Shishatskaya, Ekaterina I.: Siberian Federal University Russian Federation, Krasnoyarsk; ORCID: 0000-0001-7967-243X; Kachin, Sergei V.: Siberian Federal University Krasnoyarsk, Russian Federation
Keywords
polyhydroxyalkanoates; microparticles; rifampicin
Abstract

In this work, polyhydroxyalkanoates-based microparticles containing antibacterial drug rifampicin were obtained. The main characteristics of the microparticles were investigated: the particles yield, encapsulation efficiency and drug loading, average radius, surface morphology, polydispersity index, zeta potential and cytotoxicity towards HeLa cells. Loading of RIF into microparticles leads to the substantial decrease of its cytotoxicity

Pages
159–167
EDN
SOEIHZ
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/150144