Journal of Siberian Federal University. Biology / Polymorphism of Genes Encoding DNA Repair Enzymes in Coal Mine Workers with Lung Cancer

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Issue
Journal of Siberian Federal University. Biology. 2024 17 (1)
Authors
Timofeeva, Anna A.; Minin, Artyom V.; Bakanova, Marina L.; Zakharova, Yana A.; Torgunakov, Anastasiya V.; Prosekov, Alexandr Y.; Titov, Ruslan A.; Glushkov, Andrey N.
Contact information
Timofeeva, Anna A.: Federal Research Center of Coal and Coal Chemistry SB RAS, Kemerovo, Russian Federation; ; ORCID: 0000-0002-9063-0158; Bakanova, Marina L.: Federal Research Center of Coal and Coal Chemistry SB RAS Kemerovo, Russian Federation; ORCID: 0000-0002-1238-2427; Zakharova, Yana A.: Federal Research Center of Coal and Coal Chemistry SB RAS; Kemerovo State University Kemerovo, Russian Federation; ORCID: 0000-0003-0754-306X; Torgunakov, Anastasiya V.: Federal Research Center of Coal and Coal Chemistry SB RAS; Kemerovo State University Kemerovo, Russian Federation; ORCID: 0000-0001-5643-5001; Prosekov, Alexandr Y.: Kemerovo State University Kemerovo, Russian Federation; Titov, Ruslan A. : Federal Research Center of Coal and Coal Chemistry SB RAS Kemerovo, Russian Federation; ORCID: 0000-0002-5485-9318; Glushkov, Andrey N.: Federal Research Center of Coal and Coal Chemistry SB RAS Kemerovo, Russian Federation; ORCID: 0000- 0002-8560-6719
Keywords
miners; lung cancer; DNA repair genes
Abstract

In coal mines, workers performing basic production operations underground are exposed to a whole range of both chemical and radiation-induced carcinogenic factors. This leads to a significant increase in the risk of lung cancer in underground mine workers. The likelihood of developing cancer is affected by genetically determined features of the body’s defense systems. Specifically, much research has been devoted to the role of inherited variants of genes encoding DNA repair enzymes. However, their polymorphism in coal miners remains largely unexplored. The present study investigated associations of the polymorphism of genes encoding DNA repair enzymes – hOGG1 (rs1052133), APEX1 (rs1130409), XPD (rs13181), NBS 1 (rs1805794), and ADPRT1 (rs1136410) – with the risk of developing lung cancer in coal miners. Two hundred and thirteen miners with lung cancer were examined. The control group included 247 healthy miners of the Kemerovo Region (Western Siberia, Kuzbass). Genotyping was performed using allele-specific PCR. The study showed that the following gene variants were associated with the risk of developing cancer: polymorphism of the genes APEX1 (dominant model: ORadj=1.71; CI 95 %: 1.04–2.81), XPD (dominant model: ORadj=2.12; CI 95 %: 1.30–3.46), and ADPRT1 (recessive model: ORadj=3.00; CI 95 %: 1.08–8.33). The results of this work suggest the relationship between the polymorphism of the genes of DNA repair enzymes and the risk of lung cancer in coal mine workers

Pages
33–44
EDN
SPGETQ
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/152807

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